My Research

 

Microbes that are resistant to antimicrobials, like penicillin, can spread across human populations. These microbes contain genes that code for antimicrobial resistance, which can also spread between microbes. A resistance gene from the genome of resistant microbe can be copied/cut and pasted into another genome of a non-resistant microbe, potentially making the microbe resistant.

 

The transfer of genes between microbes happens continually but in different ways. Many of these genes are part of "mobile genetic elements" which enable the resistance genes to be copied or cut from one genome and pasted into another genome. There are three major types of mobile genetic element that can do this: phages, transposable elements and plasmids. The challenge is to discover what mobile genetic elements are associated with antimicrobial resistance genes and how prevalent these are using all microbial DNA in a sample, known as the “metagenome”.

Publications

 

Abundance and diversity of resistomes differ between healthy human oral cavities and gut

Carr, V. R., Witherden, E., Lee, S., Shoaie, S., Mullany, P., Proctor, G. B., Gomez-Cabrero, D. & Moyes, D. L., 4 Feb 2020, In : Nature Communications. 11, 1, 693.

Probing the Mobilome: Discoveries in the Dynamic Microbiome

Carr, V. R., Shkoporov, A., Hill, C., Mullany, P. & Moyes, D. L., 10 May 2020, In : Trends in Microbiology.

Conferences

 

Speaker: "Viral Dark Matter" of the human oral cavity and gut microbiome

International: Exploring Human Host-Microbiome Interactions in Health and Disease at the Wellcome Genome Campus

October 2019

Poster: Metagenomic insights into the resistome and phageome of the human oral cavity and gut

National: Medical Research Foundation's Annual Conference for PhD students

August 2019

Speaker: Abundance and diversity of resistomes differ between healthy human oral cavities and gut

National: Mathematical Foundations in Bioinformatics 2019

July 2019

Poster: Abundance and diversity of resistomes differ between healthy human oral cavities and gut (Lifebit Travel Grant)

European: ISMB ECCB

July 2019

Speaker: Metagenomic insights into the resistome and mobilome of the human oral cavity

Institutional: Plenary Session for the Faculty of Dental, Oral and Craniofacial Sciences' Postgraduate Research Day

March 2019

Poster: Metagenomic insights into the resistome of the human oral cavity (Best Poster Winner, Conference Travel Grant)

International: Antimicrobial Resistance - Genomes, Big Data and Emerging Technologies Conference at the Wellcome Genome Campus

November 2018

Speaker: Hacking Antibiotic Resistance (Best Talk Winner)

Institutional: Lighting Talk for the London Interdisciplinary Biosciences DTP Annual Conference

September 2018

Poster: Metagenomic insights into the resistome of the human oral cavity

National: Medical Research Foundation's Annual AMR Conference for PhD students

August 2018

Poster: Metagenomic insights into the resistome of the human oral cavity (Conference Travel Grant)

International: The International Human Microbiome Consortium

June 2018

Awards

 

Prize for Virtual 3 Minute Thesis Presentation

June 2020

Postgraduate Research Day, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London

Lifebit Bioinformatics Travel Grant

June 2019

Competitive travel bursary awarded to early-career researchers to attend and present at a computational biology conference

Poster Prize for the Antimicrobial Resistance - Bacterial Genomics, Big Data & Emerging Technologies Conference at the Wellcome Genome Campus
November 2018

Poster titled "Metagenomic insights into the resistome of the human oral cavity"

Bursary Award for the Antimicrobial Resistance - Bacterial Genomics, Big Data & Emerging Technologies Conference at the Wellcome Genome Campus

October 2018​

Competitive travel bursary for an international conference in Cambridge on genomics, big data and antimicrobial resistance

Winner of Best “Flash Talk” London Interdisciplinary Biosciences Doctoral Training Programme Annual Conference

September 2018​

2-minute presentation on research in genomics and antimicrobial resistance

Medical Research Foundation National PhD Training Programme in Antimicrobial Resistance Research

May 2018​

The Medical Research Foundation has created the only national training programme that will train researchers to tackle antimicrobial resistance (AMR), one of the greatest emerging threats to human health.

International Human Microbiome Congress 2018 Early Career Bursary Award

February 2018

Competitive travel bursary for an international conference on cutting-edge microbiome technologies

London Interdisciplinary Biosciences Doctoral Training Programme BBSRC Scholarship

February 2016

The London Interdisciplinary Biosciences Consortium is one of the

largest BBSRC funded Doctoral Training Partnerships in the UK. Representing an exciting collaboration between six of London's world-class universities and specialist institutions, the consortium provides students with a unique opportunity to pursue innovative interdisciplinary research projects.